Rat Model of Congenital Toxoplasmosis: Rate of Transmission
نویسنده
چکیده
The incidences of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups from chronically infected mothers are protected from congenital toxoplasmosis, rat infection could thus constitute a relevant model for immunological studies and vaccine design.
منابع مشابه
Rat model of congenital toxoplasmosis: rate of transmission of three Toxoplasma gondii strains to fetuses and protective effect of a chronic infection.
The incidence of congenital toxoplasmosis in Fischer rats infected between the 8th and 12th days of pregnancy with three different strains of Toxoplasma gondii (RH, 76K, and Prugniaud) were 58.2, 35.2, and 62.8%, respectively. No infected fetuses were collected from rats previously infected with RH or Prugniaud strain parasites, even if the rats were reinfected during pregnancy. Since pups from...
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Introduction: Infection of pregnant women with Toxoplasma gondii during pregnancy may cause congenital toxoplasmosis in embryo and a number of serious and even persistent complications in newborns. One of the most effective factors determining the rate of congenital toxoplasmosis is the rate of Toxoplasma infection or immune status of women in child-bearing ages against the parasite.This study ...
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